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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-04-12 to 2017-01-20
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch no. 41251
- Expiration date of the lot/batch: 2017-03-01 (taken from Label)

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability under test conditions: until 01 March 2017 (nominal expiry date) (taken from label)

FORM AS APPLIED IN THE TEST (if different from that of starting material): Colourless liquid
Water solubility:
ca. 1.5 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
145 mg/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
> 7.2 - < 8.5
Details on results:
The analysed concentrations for the 24-hour stirred sample were significantly higher than the analysed concentrations for the 48- and 72-hour stirred samples. Based on this, the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements. The analytical system however lacked stability during analysis of the samples. The results obtained were therefore considered as estimated values and it was decided to perform a second main study.

The stability of the analytical system during the analysis of samples from the second main study met the criterion that the coefficient of variation should be ≤ 20%. However, the maximum difference between the 24-, 48- and 72-hour stirred samples was > 15% allowed by the guidelines.

The increase in concentration with the stirring time was not observed in the first main study and therefore not considered to be related to the stirring time. Based on this, repeating the test using longer stirring times was not considered necessary.

Taking into account the results for the 48 and 72 hours stirred samples after excluding outliers (Main study 1) and the results for the 72 hours stirred samples (Main study 2), the water solubility of the test item was determined to be 1.5 mg/L.

Because AsahiklinTM AC-2000 is a highly volatile test item, it is not possible to obtain a more accurate value for the water solubility of this compound.

Main study 1 - water solubility of the test item

Stirring time

[hours]

Analysed concentration

[g/L]

Mean

[g/L]

pH

 

 

24

0.00219

0.00217

7.3

0.00227

 

 

0.00206

 

 

 

 

48

0.002101

0.00153

7.3

0.00143

 

 

0.00163

 

 

 

 

72

0.00146

0.00152

7.2

0.00159

 

 

0.0004671

 

 

1Outlier according to the Dixon’s Q-test at 90% confidence level using the six concentrations after 48and 72 hours of stirring.

Main study 2 - water solubility of the test item

Stirring time

[hours]

Analysed concentration

[g/L]

Mean

[g/L]

pH

 

 

24

0.000878

0.000881

8.1

0.000866

 

 

0.000899

 

 

 

 

48

0.00104

0.00101

8.4

0.000984

 

 

0.00101

 

 

 

 

72

0.00140

0.00148

8.5

0.00153

 

 

0.00151

 

 

Conclusions:
The water solubility of the test material (Asahiklin AC-2000) at 20°C was 1.5 mg/L.

The pH of the aqueous samples was 7.2 – 8.5.
Executive summary:

The slow-stirring flask method was applied for the determination of the water solubility of Asahiklin AC-2000.

The water solubility of the test material at 20°C was 1.5 mg/L.

The pH of the aqueous samples was 7.2 – 8.5.

Description of key information

The slow-stirring flask method was applied for the determination of the water solubility of 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexane. The water solubility of the test material at 20°C was 1.5 mg/L.

Key value for chemical safety assessment

Water solubility:
1.5 mg/L
at the temperature of:
20 °C

Additional information

A GLP-compliant study, conducted according to OECD Guideline 105 (flask method) was provided for 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexane (Charles River Laboratories Den Bosch BV., 2017a).

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