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EC number: 206-581-9
CAS number: 355-37-3
Table 2. Summary of opacity, permeability andin vitroscores
Mean In vitro
using the negative control mean opacity and mean permeability values for
the positive control
and test item.
a key guideline (OECD 437) in vitro eye irritation study, the eye
hazard potential of test material (1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorohexane)
was evaluated using the Bovine Corneal Opacity and Permeability test
test material was topically applied undiluted on the epithelium of the
bovine cornea for 10 minutes. Post exposure the cornea was thoroughly
rinsed to remove the test item and incubated for 2 hours with fresh
medium followed by opacity measurement and the permeability of the
corneas was determined after a 90 minutes incubation period with sodium
fluorescein. A negative control, physiological saline was included to
detect non-specific changes in the test system and to provide a baseline
for the assay endpoints while ethanol was used as the positive control
in this study.
negative control responses for opacity and permeability were less than
the upper limits of the laboratory
historical range indicating that the negative control did not induce
irritancy on the corneas. The
mean in vitro irritancy score of the positive control was 35 and
was within two standard deviations
of the current historical positive control mean.
test material did not induce ocular irritation through both endpoints,
resulting in a mean in vitro irritancy score of -0.2 after 10
minutes of treatment.
induced an IVIS ≤ 3, no classification is required for eye irritation or
serious eye damage.
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