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EC number: 451-160-7
CAS number: 17913-76-7
This study was entitle "Assessment of acute dermal toxicity with
Surfynol 104 in the rat".
The purpose of this study was to assess the toxicity of Surfynol 104
when administered to rats asa a single dermal dose.
The study was carried out in accordance with OECD Guidline No. 402,
"Acute Dermal Toxicity" and EEC Directive 92/96 /EEC, Part B.3, "Acute
Toxicity - Dermal". Surfynol 104 was adminestered by dermal application,
to five rats of each sex, at 2000 mg/kg body weight. Animals were
subjected to daily observations and weekly determination of body weight.
Macroscopic examination was performed at the end of the experimental
No mortality and no clinical signs of ill health were observed during
the study. Skin abnormalities on the treated area included scales and
scabs in two females between days 4 and 6. Low body weight gain or body
weight loss was noted in all animals over the first week of the study
and improved body weight gain over the second week. Macroscopic post
mortem examination of the animals at termination did not reveal any
The dermal LD50 value of Surfynol 104 in rats of either sex was
established as exceeding 2000 mg/kg/ body weight.
Based on these results and according to the EEC criteria for
classification and labeling requirements for dangerous substances and
preparations (EEC Directive 91/325/EEC, Amendment to Annex VI of the EEC
Directive 67/548/EEC). Surfynol 104 cannot be classified and has no
obligatory labeling reqiurement.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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