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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
October 1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The category has been evaluated for validity to read-across as documented in the CCRF in section 0

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
according to specifications for such substances set forth by the Manufacturing Chemist´s Association, Inc.:
" ... a toxic substance falls within the following category: "a substance that has a median lethal concentration (LC50) in air of more than ..... 2 milligrams per liter but not more than 20 milligrams per liter of mist ..... when administrered by continuous inhalation for one hour or less to albino rats weighing between 200 grams and 300 grams each ... "
GLP compliance:
no
Test type:
other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
5 % of aqueous solution

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
air
Duration of exposure:
ca. 1 h
Concentrations:
20 mg of mist per liter
No. of animals per sex per dose:
5 male and
5 female
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Remarks on result:
not determinable due to absence of adverse toxic effects

Any other information on results incl. tables

Ocular and nasal irritation as well as a reduction in spontaneous activity were noted in all animals at the end of the one-hour exposure period. These symptoms disappeared within three hours.

All rats survived the one-hour exposure and the 14 -day observation period (post exposure).

All animals maintained a normal appearance and gained weight over the observation period. No evidence of gross lesions was found in the animals autopsied. Body weight data are presented in the following summary:

Material              Sex       Initial       Final       Change

Surfynol 104       M       176 g       288 g       + 112 g

- " -                    F       211 g       239 g       + 28 g

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Based upon the results of this study, it was concluded that the Surfynol 104 sample submitted was not a toxic substance by inhalation according to specifications for such substances set forth by the Manufacturing Chemist´s Association, Inc.:
" ... a toxic substance falls within the following category: "a substance that has a median lethal concentration (LC50) in air of more than ..... 2 milligrams per liter but not more than 20 milligrams per liter of mist ..... when administrered by continuous inhalation for one hour or less to albino rats weighing between 200 grams and 300 grams each ... "
Executive summary:

Ocular and nasal irritation as well as a reduction in spontaneous activity were noted in all animals at the end of the one-hour exposure period. These symptoms disappeared within three hours.

All rats survived the one-hour exposure and the 14 -day observation period (post exposure).

All animals maintained a normal appearance and gained weight over the observation period. No evidence of gross lesions was found in the animals autopsied. Body weight data are presented in the following summary:

Material              Sex       Initial       Final       Change

Surfynol 104       M       176 g       288 g       + 112 g

- " -                    F       211 g       239 g       + 28 g