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EC number: 451-160-7
CAS number: 17913-76-7
Test Substance Concentration Proliferative response
(% v/v) (DPM/lymph node)
0 (vehicle control) 1580
2,4,7,9-tetramethyldecane-4,7-diol was considered to be a non-sensitizer under the conditions of the test.A study was performed to assess the skin sensitization potential of the test material in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear. The method was designed to meet the requirements of OECD Guideline 429.Following a preliminary screening test, three groups, each of five animals, were treated with 50 ml (25ml per ear) of the test material as a solution in acetone/olive oil 4:1 at concentrations of 10%, 25%, and 50% v/v. A further group of five animals were treated with acetone/olive oil 4:1 alone.The Stimulation Index (SI) expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control group are as follows:Concentration (% v/v) in Acetone/olive oil 4:1 Stimulation Index (SI) Result10 1.19 Negative25 2.16 Negative50 2.51 Negative2,4,7,9-tetramethyldecane-4,7-diol did not meet the criteria for classification as a sensitizer according to EU labeling regulations Commission Directive 2001/59/EC. No symbol and risk phrase are required.
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