4,7-Decanediol, 2,4,7,9-tetramethyl-

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: according to EC Directive 92/69/EEC and Regulation EC/440/2008 guideline methods under GLP conditions

Qualifier:

according to guideline

Guideline:

EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

GLP compliance:

yes

Type of method:

HPLC estimation method

Media:

soil

Details on study design: HPLC method:

Because the test substance is not liable to undergo ionisation, it was only necessary to
perform an evaluation under one test condition which was representative of
environmental conditions. This was achieved by using a mobile phase of acetonitrile
(45 parts) and water (55 parts), both reagents of HPLC grade.
The dead time of the column and system, T0, was measured using formamide as a nonretained
solute (void volume marker). The HPLC column was calibrated for distribution
coefficient against retention time using calibration substances of known distribution
coefficient dissolved in appropriate mobile phase. The test substance was dissolved in
mobile phase and the retention time recorded. Duplicate estimations were performed for
each series.

The distribution coefficient was estimated by the HPLC method using isocratic elution.
The procedure conformed to those outlined in OECD Guideline 121 and EC Directive
2001/59/EC Method C19. The following HPLC system was used:
TABLE 12
Instrumental Conditions
Pump : Jasco PU 980
Injection volume : 50 μL
Detector : Jasco UV-975 set to 210 nm
Column : Zorbax CN, 250 x 4.6 mm
Mobile phase : As described below
Flow rate : 1.0 mL/min
Column temperature : 25°C

Type:

log Koc

Value:

ca. 3.88

Temp.:

25 °C

Details on results (HPLC method):

The distribution coefficient on soil (log Koc) of the test item, was estimated by
HPLC simulation procedure. The test substance eluted as a single component with a
retention time equivalent to a log Koc value of 3.88, and within a 95% confidence range
of 3.46 to 4.44.

The quantities of each calibration and test substance injected onto the column are given in
Table 13, together with appropriate purity and reference data.

TABLE 13
Calibration and Test Substance Data
Compound Purity (%) Log Koc Value Mass on Column (μg)
Formamide >99 N/A 7.48
Acetanilide 97 1.25 0.44
Methyl benzoate 99 1.80 0.60
Linuron 99.8 2.59 0.24
Naphthalene >99 2.75 0.07
Phenanthrene 98 4.09 0.30
DDT 98 5.63 1.08
test item 98.3 N/A 630.50

Validity criteria fulfilled:

yes

Conclusions:

The distribution coefficient on soil (log Koc) of 2,4,7,9-tetramethyldecane-4,7-diol, was estimated by HPLC simulation procedure. The test substance eluted as a single component with a retention time equivalent to a log Koc value of 3.88, and within a 95% confidence range of 3.46 to 4.44.

Executive summary:

The distribution coefficient on soil (log Koc) of 2,4,7,9-tetramethyldecane-4,7-diol, was estimated by HPLC simulation procedure. The test substance eluted as a single component with a retention time equivalent to a log Koc value of 3.88, and within a 95% confidence range of 3.46 to 4.44.

Description of key information

The distribution coefficient on soil (log Koc) of 2,4,7,9-tetramethyldecane-4,7 -diol, was estimated by HPLC simulation procedure. The test substance eluted as a single component with a retention time equivalent to a log Koc value of 3.88

Key value for chemical safety assessment

Koc at 20 °C:

7 585.776