Registration Dossier

Administrative data

Endpoint:
biotransformation and kinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: according to EC Directive 92/69/EEC and Regulation EC/440/2008 guideline methods under GLP conditions This data is valid as documented CCRF for this category (Acetylenic geminalic diols)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report Date:
1999

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: OECD 301 B, 92/93/EEC, C.4-C
Deviations:
no
GLP compliance:
yes
Type of medium:
aquatic

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Batch-#: 11029
Purity: 98.3 %

Results and discussion

Transformation products:
not measured

Applicant's summary and conclusion

Conclusions:
2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was not readily biodegradable under the conditions of the modified Sturm test presently performed. Approximately 5 percent degraded in 28 days.
Executive summary:

2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was not readily biodegradable under the conditions of the modified Sturm test presently performed. Approximately 5 percent degraded in 28 days.

2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was tested for its ready biodegradability in the carbon dioxide (CO2) evolution test (modified Sturm test) at 36.3 ml per 2 litres, corresponding with 12 mg TOC/l.

The Theoretical CO2 production (ThCO2) of 2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was calculated to be 2.72 mg CO2/mg, corresponding with 2.42 mg CO2/ml.

The relative degradation values calculated from the measurements performed during the test period revealed no significant degradation of 2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol. In the toxicity control of 2,4,7,9-Tetramethyl-5-Decyne-4,7-Diol was found to be not inhibitory.

Since all acceptability criteria prescribed by the protocol were met, this study was considered to be valid.