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EC number: 451-160-7 | CAS number: 17913-76-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Non-sensitizer according to OECD TG 429
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- GLP Statement
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Limited, Bicester, Oxon (1 mouse), UK and B&K Universal Ltd, Hull UK (20 mice)
- Age at study initiation: 8 to 12 weeks
- Weight at study initiation: 15 to 23 g
- Housing: suspended solid-floor polypropylene cages furnished with softwood woodflakes
- Certified Rat and Mouse Diet (Code 5LF2): ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 25°C
- Humidity (%): 30 to 70%
- Air changes (per hr): 15 per hour
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0% (vehicle control)
10%
25%
50% - No. of animals per dose:
- 5
- Details on study design:
- Method: OECD TG 429 Skin Sensitation: LLNA
Species/Strain: Mouse/CBA/CaOlaHsd
Vehicle: Acetone/olive oil (4:1)
Remarks: No significant deviations - Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: see field below (Any other information on results incl. tables)
- Key result
- Parameter:
- SI
- Value:
- 1.19
- Test group / Remarks:
- 10 %
- Key result
- Parameter:
- SI
- Value:
- 2.16
- Test group / Remarks:
- 25 %
- Key result
- Parameter:
- SI
- Value:
- 2.51
- Test group / Remarks:
- 50 %
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was considered to be a non-sensitiser under the conditions of the test.
The test material did not meet the criteria for classification as a sensitizer according to EU labelling regulations Commission Directive 2001/59/EC. No symbol and risk phrase are required. - Executive summary:
2,4,7,9-tetramethyldecane-4,7-diol was considered to be a non-sensitizer under the conditions of the test.
A study was performed to assess the skin sensitization potential of the test material in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear. The method was designed to meet the requirements of OECD Guideline 429.
Following a preliminary screening test, three groups, each of five animals, were treated with 50 ml (25ml per ear) of the test material as a solution in acetone/olive oil 4:1 at concentrations of 10%, 25%, and 50% v/v. A further group of five animals were treated with acetone/olive oil 4:1 alone.
The Stimulation Index (SI) expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control group are as follows:
Concentration (% v/v) in Acetone/olive oil 4:1 Stimulation Index (SI) Result
10 1.19 Negative
25 2.16 Negative
50 2.51 Negative
2,4,7,9-tetramethyldecane-4,7-diol did not meet the criteria for classification as a sensitizer according to EU labeling regulations Commission Directive 2001/59/EC. No symbol and risk phrase are required.
Reference
Test Substance Concentration Proliferative response Stimulation Index
(% v/v) (DPM/lymph node) (Test/Control Ratio)
0 (vehicle control) 1580 -
10 1878 1.19
25 3414 2.16
50 3972 2.51
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A study was performed to assess the skin sensitization potential of the test material in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear. The method was designed to meet the requirements of OECD Guideline 429.
Following a preliminary screening test, three groups, each of five animals, were treated with 50 ml (25ml per ear) of the test material as a solution in acetone/olive oil 4:1 at concentrations of 10%, 25%, and 50% v/v. A further group of five animals were treated with acetone/olive oil 4:1 alone.
The Stimulation Index (SI) expressed as the mean radioactive incorporation for each treatment group divided by the mean radioactive incorporation of the vehicle control group are as follows:
Concentration (% v/v) in Acetone/olive oil 4:1 Stimulation Index (SI) Result
10 1.19 Negative
25 2.16 Negative
50 2.51 Negative
2,4,7,9-tetramethyldecane-4,7-dioldid not meet the criteria for classification as a sensitizer according to EU labeling regulations Commission Directive 2001/59/EC. No symbol and risk phrase are required.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There is no information available for respiratory sensitisation. Therefore, there is a data gap in this respect. However, the data gap cannot be fulfilled with experimental data, since there is no internationally accepted animal model for respiratory sensitisation. In case human data for respiratory sensitisation emerges, this will be taken into account.
Justification for classification or non-classification
According to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Part 3 Chapter 3.4 this substance is not causing concern to be sensitizing.
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