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EC number: 451-160-7
CAS number: 17913-76-7
The purpose of this study was to evaluate
the possible toxicity of 2,4,7,9-Tetramethyl-5-decyne-4,7-diol,
when fed to the rat during a single generation reproduction study and
for ninety one days to the F1a weanlings. The test material was mixed
into the rats’ feed to provide dose levels of 0, 500, 1000, and 2000
mg/kg/day. Sexually mature Sprague-Dawley albino rats were divided into
four groups, each consisting of ten male and twenty female rats. All Fo
male rats, both test and control, were fed their respective diets until
their litters reached the age of 21 days for weaning, when the Fo dams
were sacrificed. The weanlings were randomized to their respective
groups and carried on the same dose levels to the termination of the
experiment. The only pertinent findings observed in the Fo parents were:
1. Slight decrease in the mean weaning weight of both male and female
pups of the high-dose group, 2. Slight decrease in lactation indices of
the high-dose group, 3. Decreased body weight and feed consumption of
the high-dose female group, 4. Normal histology of the reproductive
organs in the Fo parents. The following pertinent findings were observed
in the F1a rats: 1. Slight decrease in the mean rate of body weight gain
in the mid- and high-dose male and female rats; there was also
significant decrease in this parameter in the low-dose male group during
the first eight weeks, 2. Normal mean hematological findings, clinical
chemistry findings, and urinalysis findings after 91 days on test, 3.
Significant increase in the liver weight of the mid- and high-dose male
and female test groups with corresponding increase in the liver-to-body
weight ratios, 4. Corresponding histopathology of the liver of the mid-
and high-dose male and female rats, showing mild to moderate
centrilobular cloudy swelling of hepatocytes.
when fed to rats under the conditions of this experiment, showed no
effect at 500 mg/kg/day but did have a toxic effect in the F1a
generation at greater than or equal to 1,000 mg/kg/day while in the
reproduction phase of this experiment there was a toxic effect at the
2,000 mg/kg/day level, a borderline effect at the 1,000 mg/kg/day level
and no effect at 500 mg/kg/day.
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