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EC number: 231-901-9
CAS number: 7778-39-4
gene expression values for each cell cycle gene from the isolated neural
tubes of LM/Bc embryos during neurulation
shown as mean±SEM
Significantly different than control values, p<0.05
greater than control values at the other time points for this gene,
less than control values at the other time points for this gene, p<0.05
less than control values at 10:00 and 10:12 for this gene, p<0.05
developmental toxicity study, pregnant
strain (LM/Bc) mice were injected intraperitoneally with sodium arsenate
at 40 mg/kg bw during gestation day (GD) 7:12 (day:hour) and 8:12.
Control group animals were injected with physiologic saline. Neural
tubes were then isolated from both control and arsenic treated embryos
at GD 9:00, 9:12, 10:00, and 10:12, which encompasses all the stages of
neurulation for this murine strain. Using the molecular techniques of in
situ transcription and antisense RNA amplification (RT/aRNA) the
expression pattern for bc1-2, p53, wee-1 and wnt-1 was analyzed at each
of these time points.
of sodium arsenate causes exencephaly in 90 to 100% of the exposed
fetuses. In the neural tubes isolated from control embryos, the
expression of all four genes (bc1-2, p53, wee-1, and wnt-1) were
significantly altered as neurulation progressed, demonstrating their
developmental regulation. Following arsenate treatment, however, there
was a significant upregulation in the expression of bc1-2 and p53 at
gestational day 9:00, compared to their control values. The heightened
expression of both these genes suggests that arsenic inhibits cell
proliferation, rather than inducing apoptosis, which delayed neural tube
closure and led to the neural tube defects in exposed embryos.
the test conditions, arsenic induces the neural tube defects in exposed
embryos of murine strain (LM/Bc) mice.
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