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EC number: 231-901-9
CAS number: 7778-39-4
In an acute oral toxicity study performed
similarly to OECD guideline 401 and in compliance with GLP, groups of
Crl:CD-1 (ICR) BR mice (5/sex/dose) were given a single oral dose of
arsenic acid (75% w/w) at 75, 100 or 200 mg/kg bw. Animals were then
observed for mortality, clinical signs and bodyweights for 14 days and
were all macroscopically necropsied after death or sacrifice. A
preliminary range-finding test was also conducted on 1 mice/sex/dose at
four dose levels.
Mortalities were 0, 20 and 70% at 75, 100
and 200 mg/kg bw, respectively. All animals showed expected gain in
bodyweight over the study period. Clinical signs noted were diarrhoea,
hypoactivity, ataxia and tremors which resolved completely by Day 4 in
surviving animals. Necropsy of the surviving animals at 75 mg/kg bw
revealed stomach containing dark brown, semifluid material (in one male)
and uterus lumen filled with clear fluid (in one female). Necropsy of
the dead animals revealed brown stained perineum.
Oral LD50 Combined = 149.6 mg/kg bw (114.4
Oral LD50 Males = 141.4 mg/kg bw
Oral LD50 Females =160.4 mg kg bw(107.1-240.3)
The oral LD50 for arsenic acid (75% w/w) is
in the range of 50-200 mg/kg bw in mice therefore it is classified as ‘T;
R25 Toxic if swallowed’ according to the Annex VI of the Directive
67/548/EEC and ‘category 3’ according to the CLP Regulation (EC) No.
This study is acceptable and satisfies the guideline
requirement for an acute oral study (OECD 401) in mice.
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