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EC number: 231-901-9
CAS number: 7778-39-4
Table 1: Individual dermal irritation score
at 4.5 hours post-exposure
Animal No. 1
Animal No. 2
Animal No. 3
Animal No. 4
Animal No. 5
Animal No. 6
In a primary dermal irritation study
performed similarly to OECD guideline 404 and in compliance with GLP,
six (3/sex) New-Zealand White rabbits were dermally exposed to 0.5 mL of
undiluted Desiccant L-10 (arsenic acid), under a semi-occlusive bandage
for 4 hours to clipped skin of the dorsal surface (scapular to lumbar
region). Animals were then observed for 24 hours. Irritation was scored
by the method of Draize (1959).
Three of the six animals exhibited tissue
destruction (necrosis) at the application site at 4.5 hours
post-exposure (30 min. after removal of wrappings); the other three
animals exhibited moderate to severe erythema and edema. All six animals
were found dead within 24 hours after dosing. In this study, arsenic
acid was found to be corrosive when applied topically to the rabbit.
Under the test conditions, arsenic acid is
classified as corrosive to the skin, ‘R34 Causes burns’ according to the
criteria of Annex VI of the Directive 67/548/EEC and ‘ Category 1:
Corrosive 1C’ in CLP Regulation (EC) No. 1272/2008.
This study is acceptable and satisfies the
guideline requirement for an acute dermal irritation study (OECD 404).
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