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EC number: 231-901-9
CAS number: 7778-39-4
In an acute inhalation toxicity study
performed similarly to OECD guideline 403 and in compliance with GLP,
groups (5/sex) of CD-1 mice were exposed (whole-body) to aerosol
atmosphere of arsenic acid at concentrations of 0.57, 1.01 or 2.41 mg/L
(analytical TWA) corresponding to 24.9, 49.1 or 206.7 mg/L (nominal) for
4 hours. Animals were then observed for mortality, clinical signs and
bodyweights for 14 days and were all macroscopically necropsied after
death or sacrifice.
0, 90 and 80% at 0.57, 1.01 and 2.41 mg/L (analytical), respectively.
Clinical signs noted during the study included respiratory distress,
increased secretory responses, signs of poor condition and diminution of
body weight gain. At necropsy, macroscopic examination revealed lesions
in the respiratory system.
inhalation LC50 for males and females were determined to be 0.794
(0.548-1.149) and 1.153 (0.410-1.897) mg/L (analytical), respectively.
The acute inhalation combined LC50 was 1.040 (0.512-1.567) mg/L
Under the test conditions, the inhalation
LC50 for arsenic acid (aerosol) is 1 mg/L in mice therefore it is
classified as ‘R23 Toxic by inhalation’ according to the Annex VI of the
Directive 67/548/EEC and ‘Category 3’ in the CLP Regulation (EC) No.
This study is acceptable and satisfies the guideline
requirement for an acute inhalation study (OECD 403).
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