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EC number: 231-901-9 | CAS number: 7778-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From March 06 to May 09, 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study performed similarly to OECD Guideline 402 with minor deviation: no data on test substance purity
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- no data on purity
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- no data on purity
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Arsenic acid
- EC Number:
- 231-901-9
- EC Name:
- Arsenic acid
- Cas Number:
- 7778-39-4
- Molecular formula:
- H3AsO4
- IUPAC Name:
- arsoric acid
- Details on test material:
- - Name of test material (as cited in study report): Desiccant L-10
- Source: Pennwalt Corporation, USA
- Physical state: Light blue, clear liquid
- Date of receipt: January 4, 1985
- Lot/batch No.: 8158
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton-Dutchland, Inc., Denver, USA
- Age at study initiation: Young adults (at least 8 weeks old)
- Weight at study initiation: Males: 2.2-2.8 kg; females: 2.2-2.7 kg
- Housing: Individually housed in suspended, stainless steel cages
- Diet (e.g. ad libitum): Lab Rabbit Chow HF (Purina #5326), ad libitum
- Water (e.g. ad libitum): Municipal water supply (Elizabethtown Water Co.), ad libitum
- Acclimation period: 22, 23 or 24 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 60-70 °F
- Humidity (%): 30-70%
- Photoperiod (hours dark / hours light): 12 hours dark / 12 hours light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Trunk (dorsal surface)
- % coverage: At least 10% of the body surface area
- Type of wrap if used: Test material was placed directly onto a strip (4” x 12”) of 8-ply gauze; applied on the clipped skin of the animal and then wrapped with an impervious plastic sleeve.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Test sites were not washed but wiped free of excess test material
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1, 0.21, 0.41, 0.82 and 1.6 mL/kg bw - Duration of exposure:
- 24 hours
- Doses:
- 200, 400, 800, 1600 and 3200 mg/kg bw
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed twice daily for viability; clinical signs were observed at 1, 2 and 4 hours after dosing and daily thereafter for 14 days; weighed pre-test, at the time of clipping and on Day 7 and 14 or at death
- Necropsy of survivors performed: Yes; surviving animals were killed on Day 14 by an intravenous overdose of sodium pentobarbital and examined grossly - Statistics:
- LD50 was estimated using probit analysis (Miller LC and Tainter ML, 1944).
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 750 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 944 - 2 556
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: CL cannot be calculated due to distribution of mortality
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 583 - 2 417
- Mortality:
- - At 200, 400 and 800 mg/kg bw: No deaths
- At 1600 mg/kg bw: 2/5 males died within 2 days
- At 3200 mg/kg bw: All males and females died within 2 days - Clinical signs:
- other: - 9/10 animals in 3200 mg/kg bw group which died within 24 hours were hypoactive four hours post-dosing; one animal which died on Day 2 exhibited hypoactivity, irregular breathing, nasal discharge and decreased food consumption prior to death. - No antemo
- Gross pathology:
- - Necropsy of the dead animals revealed dermal lesions and abnormalities in the lungs and gastrointestinal tract associated with postmortem autolytic changes, antemortem stress and/or normal physiologic variation.
- Necropsy of the surviving animals revealed no abnormalities. - Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, the acute dermal LD50 for Desiccant L-10 was calculated to be 2000 (1583-2417) mg/kg bw in rabbits therefore it is classified as ‘R21 Harmful in contact with skin’ according to the Annex VI of the Directive 67/548/EEC and ‘Category 4’ according to the CLP Regulation (EC) No. 1272/2008.
- Executive summary:
In an acute dermal toxicity study performed similarly to OECD guideline 402 and in compliance with GLP, groups of New Zealand White rabbits (5/sex/dose) received a single dermal dose of Desiccant L-10 at 200, 400, 800, 1600 and 3200 mg/kg bw on clipped area of the trunk representing at least 10% of the total body surface area. The application was occluded and exposure was for 24 hours. Animals were then observed for mortality, clinical signs and bodyweights for 14 days and were all macroscopically necropsied after death or sacrifice.
Mortalities were 0, 20 and 100% at 200-800, 1600 and 3200 mg/kg bw, respectively. All animals exhibited minimal weight changes (± 0.2 mg/kg bw) except one male at 800 mg/kg bw (48% weight loss). Severe abnormalities (hypoactivity, irregular breathing, nasal discharge and decreased food consumption) were observed in animals which died within 2 days. Clinical signs noted in surviving animals were decreased food consumption, occasional occurrences of soft or mucoidal stool and other isolated abnormalities. Most surviving animals were free of abnormalities at study termination. Necropsy of the dead animals revealed dermal lesions and abnormalities in the lungs and gastrointestinal tract associated with postmortem autolytic changes, antemortem stress and/or normal physiologic variation. Necropsy of the surviving animals revealed no abnormalities. The acute dermal LD50 for males and females were determined to be 1750 (944-2556) and 2300 mg/kg bw, respectively. The combined dermal LD50 was calculated to be 2000 (1583-2417) mg/kg bw.
Dermal reactions noted in several animals were necrosis followed by eschar formation and exfoliation.
Under the test conditions, the acute dermal LD50 for Desiccant L-10 was calculated to be 2000 (1583-2417) mg/kg bw in rabbits therefore it is classified as ‘R21 Harmful in contact with skin’ according to the Annex VI of the Directive 67/548/EEC and ‘Category 4’ according to the CLP Regulation (EC) No. 1272 /2008.
This study is acceptable and satisifes the guideline requirement for an acute dermal toxicity study (OECD 402).
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