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EC number: 231-901-9
CAS number: 7778-39-4
In an in vitro chromosomal aberration assay
conducted similarly to OECD Guideline 473, whole blood cultures were
incubated for 72 hours and treated with various concentrations (1-10-10
µM) of sodium arsenite for the last 24 hours. Also, mitotic arrest was
evaluated in cultures treated for the last 2 hours. Cells were harvested
and samples were processed for evaluation of aneuploidogenic and mitotic
arrest. Number of chromosomes in 200 metaphases of first and second
division cells was scored.
Positive controls (colcemid at 10-2 µM)
induced the appropriate response. A dose-related effect was observed:
highest concentration (10-2 µM sodium arsenite) induces 28.33 and 22.4%
hyperploid cells in first and second division respectively and 29%
tetraploid cells. Sodium arsenite produced 40.24 and 12.93% of the
mitotic arrestant effect at 10-2 µM and 10-10 µM, respectively). A
different individual susceptibility effect was observed in both
parameters and confirmed with the chromosome aberrations levels induced
by arsenic in the same donors.
Under the test conditions, sodium arsenite
was found to have an aneuploidogenic and a mitotic arrestant effect in
cultured human lymphocytes.
The authors of the report did not include a
comment in their summary of the report, but a positive effect was also
observed in terms of an increase in chromosome aberrations.
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