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EC number: 231-901-9
CAS number: 7778-39-4
Absorption of sodium arsenate increased linearly in all exposure
vehicles, with a constant fraction of the dose being absorbed.
In aqueous vehicle (100 µL), maximum absorption (62% of the applied
dose) was obtained and the skin contained a higher level of the compound
than the receptor fluid.
- Solid provided the least (<0.3% of the applied dose) absorption of the
chemical, with the major portion (68%) of the absorbed dose residing
within the skin
compartment contained higher percentages of the permeated dose than the
receptor fluid in all cases with the highest value (> 89% of permeated
dose) was obtained with 250 µL aqueous vehicle
Short term (1 hour) dermal exposure to arsenate in water resulted in the
passage of the chemical into the skin, which on further perfusion (23
hours) passed into receptor fluid
permeation rates of sodium arsenate through mouse skin from different
Applied dose (ng)
Water (100 µL)
Water (250 µL)
of applied dose/4 hours.
are mean ± SD of atleast five determinations
absorption study was conducted to determine the dermal absorption of
sodium arsenate (73As) in various donor vehicles (aqueous and
solid) on the skin surface of female B6C3F1 mice under
various conditions of exposure. Doses of 5, 50, 500 or 5000 ng were
applied to the skin surface (area = 0.64 cm2) as the solid
compound, in aqueous vehicle (100 and 250 µL) or in soil (23 mg/cm2).
This experiment was conducted for 24 hours using previously clipped
full-thickness dorsal skin in a flow-through system with HEPES-buffered
Hanks' balanced salt solution as the receptor fluid. Dermal absorption
was quantified by summing the amounts of arsenate-derived radioactivity
using a gamma counter in the receptor fluid and skin following washing
of the skin surface to remove unpenetrated compound.
of sodium arsenate increased linearly in all exposure vehicles, with a
constant fraction of the dose being absorbed. In 100 µL aqueous vehicle,
maximum absorption (62% of the applied dose) was obtained and the skin
contained a higher level of the compound than the receptor fluid. While,
solid provided the least (<0.3% of the applied dose) absorption and the
major portion (68%) of the absorbed dose residing within the skin.
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