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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1976
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Very concise test report, no information on test protocol available.
Justification for type of information:
No study was selected since weight of evidence approach was applied.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Inhalation toxiticy test with an exposure of 6 hours.
GLP compliance:
no
Remarks:
Study performed in 1976
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N'-di-sec-butyl-p-phenylenediamine
EC Number:
202-992-2
EC Name:
N,N'-di-sec-butyl-p-phenylenediamine
Cas Number:
101-96-2
Molecular formula:
C14H24N2
IUPAC Name:
N,N'-di-sec-butyl-p-phenylenediamine
Details on test material:
- Name: Santoflex 44
- Lot n°: 274777

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Sample temperature: ambient
Chamber temperature: 27°C
Chamber humidity: 80%
Chamber volume: 35L
Air flow rate: 4.0 L/min

Initial sample: 69.1 g
Recovered sample: 68.7 g
Condensed sample: 0.0 g
Vaporized sample: 0.4 g
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
0.2 mg/L
No. of animals per sex per dose:
6 males
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 0.2 mg/L air
Based on:
test mat.
Exp. duration:
6 h
Mortality:
no mortalities
Clinical signs:
other: no toxic signs
Other findings:
Viscera appeared normal in survivors (14d).

Applicant's summary and conclusion