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EC number: 202-992-2
CAS number: 101-96-2
For 44PD, read-across from 7PPD is
done. There is one study available which assesses toxicity to soil
macroorganisms. This study on 7PPD was designed to comply with the
- OECD Guideline No. 222 for the
Testing of Chemicals "Earthworm Reproduction Test (Eisenia
fetida/Eisenia andrei)" adopted April 13, 2004
- ISO Guideline 11268-2 "Soil quality
- Effects of pollutants on earthworms (Eisenia fetida) Part 2:
Determnation of effects on reproduction" adopted July 1998
The purpose of this study was to
determine a NOEC/LOEC and/or an EC50 for the effects of the test item on
the reproduction (56 days after application), mortality and the biomass
development (28 days after application) of the earthworm Eisenia fetida
(Lumbricidae) by dermal and alimentary uptake using a standardised
artificial soil. The test item was tested in five concentrations and was
mixed with the substrate. Four replicates per concentration, eight
solvent control replicates and additionally four deionised water control
replicates (ten worms per replicate) were tested.
7.5 and 1.3% mortality was observed at
the control and the solvent control, respectively. At all concentrations
of the test item 0-7.5% mortality was determined.
Statistical analysis (Williams test;
1-sided, p ≤ 0.05) showed a significant difference concerning the number
of juveniles between the solvent control and the concentrations of 178
and 316 mg 7PPD/kg. All other concentrations tested did not differ
statistically significant from the solvent control.
Therefore, the NOECReproductionwas
determined to be 100 mg 7PPD/kg soil (dw) and accordingly, the LOECReproductionas
178 mg 7PPD/kg soil (dw). This corresponds (after correction for
molecular weight) to the NOECReproduction of 78 mg 44PD/kg
soil (dw) and accordingly, the LOECReproduction of 138.8 mg
44PD/kg soil (dw).
Since inhibition of reproduction was <
50% compared to the solvent control in all concentrations of the test
item tested (31.3% inhibition was observed in the highest concentration)
no EC50 value was calculated.
The long-term toxicity
of 7PPD to earthworm (Eisenia fetida) was tested according OECD
Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia
andrei)) and ISO 11268-2 (Effects of Pollutants on Earthworms. 2.
Determination of Effects on Reproduction). During
56 days exposure an NOEC(Reproduction) was determined to be 100 mg
7PPD/kg soil (dw) and the LOEC(Reproduction) as 178 mg 7PPD/kg soil
(dw). After correction for molecular weight, this corresponds to an NOEC
(reproduction) of 78 mg 44PD/kg soil (dw) and an LOEC (reproduction) of
138.8 mg 44PD/kg soil (dw).
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