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Registration Dossier
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EC number: 202-992-2 | CAS number: 101-96-2
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source available. No data on test protocol.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Toxicological Evaluations 12 - Potential Health Hazards of Existing Chemicals.
- Author:
- BG Chemie
- Bibliographic source:
- Toxicological Evaluations, volume 12, section "N,N'-di-sec-butyl-p-phenylenediamine", p. 193-203. Published by Springer.
Materials and methods
- Limit test:
- yes
Test material
- Reference substance name:
- N,N'-di-sec-butyl-p-phenylenediamine
- EC Number:
- 202-992-2
- EC Name:
- N,N'-di-sec-butyl-p-phenylenediamine
- Cas Number:
- 101-96-2
- Molecular formula:
- C14H24N2
- IUPAC Name:
- N,N'-di-sec-butyl-p-phenylenediamine
- Details on test material:
- technical grade
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- clipped dorsal skin
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- 5 days / week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
90 mg / kg bw
Basis:
nominal per unit body weight
- No. of animals per sex per dose:
- 3 male rats
- Control animals:
- yes
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- effects observed, treatment-related
- Description (incidence and severity):
- irritant effects and ulceration of the skin
- Mortality:
- no mortality observed
- Details on results:
- No changes in haematological parameters other than granulocytosis were observed in the treated rats compared with 3 control rats.
The methaemoglobin level was not increased.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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