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EC number: 202-992-2
CAS number: 101-96-2
For 44PD, read-across
from 7PPD is done to conclude on the terrestrial toxicity of 44PD. More
information on the read-across is provided in the read-across
In a first study, the
long-term toxicity of 7PPD to earthworm (Eisenia fetida) was tested
according OECD Guideline 222 (Earthworm Reproduction Test (Eisenia
fetida/Eisenia andrei)) and ISO 11268-2 (Effects of Pollutants on
Earthworms. 2. Determination of Effects on Reproduction). During
56 days exposure an NOEC(Reproduction) was determined to be 100 mg
7PPD/kg soil (dw) and the LOEC(Reproduction) as 178 mg 7PPD/kg soil
(dw). After correction for molecular weight, this corresponds to an NOEC
(reproduction) of 78 mg 44PD/kg soil (dw) and an LOEC (reproduction) of
138.8 mg 44PD/kg soil (dw).
In a second study, the
chronic toxicity of
7PPD to terrestrial plants was tested according to OECD Guideline 208
(Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test).
Five to seven different test item concentrations per species were tested
against a solvent control (acetone) with each of the six plant species.
No significant effect on seedling emergence or mortality was observed
for any of the six test species. Effects were observed for shoot length
and fresh weight. Shoot length and shoot fresh weight of B. napus
seedlings were significantly reduced at concentrations of 15.6 and 62.5
mg 7PPD/kg soil dw, respectively. After correction for molecular weight,
this corresponds to 12.2 and 48.8 mg 44PD/kg soil dw. Hence, B. napus
was the most sensitive species with regard to shoot length and weight.
In a 3rdstudy,
the toxicity of 7PPD to soil microorganisms was assessed. At test-item
concentrations of 10.0 mg 7PPD/kg soil dw and 100 mg 7PPD/kg soil dw
nitrate concentration in soil was statistically significantly
increased.The LOEC and NOEC were determined to be 333 mg 7PPD/kg soil dw
and 100 mg 7PPD/kg soil dw, respectively. After correction for molecular
weight, this corresponds to LOEC of 259.8 mg 44PD/kg soil dw and a NOEC
of 78 mg 44PD/kg soil dw. Due to the lacking of a dose-response
relationship effective concentrations (ECx) could not be calculated.
Based on the above results, the test item, 7PPD is considered to have no
adverse long-term effects on nitrate formation in soil at concentrations
up to and including 100 mg 7PPD/kg soil dry weight. Similarly, it can be
concluded that 44PD has no long-term effects on nitrate formation in
soil at concentrations up to and including 78 mg 44PD/kg soil dw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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