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EC number: 202-992-2
CAS number: 101-96-2
Santoflex 44 antioxidant was administered to fasted albino rats of both
sexes through oral gavage of a 392 mg/ml solution in corn oil. The
administered volume was adapted to the animal's body weight and the
target dose. The rats were observed for clinical signs and mortality for
14 days. After day 15 the surviving animals were sacrificed. Necropsies
were performed on all animals.
The acute oral LD50 was calculated to be 271 mg/kg bw, with 95%
confidence limits of 146 and 366 mg/kg. Commonly observed clinical
abnormalities included lethargy, ataxia, ptosis and abnormal urinary
coloration (green and/or red/brown). Necropsy findings including
gastrointestinal inflammation (in many cases reaching the severity of
hemorrhage), gastrointestinal distension, and red, fluid filled gastric
masses indicated that toxicity to gastrointestinal tissue may have
contributed to lethality in virtually all of the rats that died on the
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