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EC number: 239-701-3
CAS number: 15625-89-5
repeated dermal toxicity study was performed to assess the dermal
irritation caused by trimethylolpropane triacrylate (TMPTA) in New
Zealand White rabbits.
of New Zealand White rabbits (5/sex/dose) received topical application
of TMPTA (500 mg/kg bw) to the back, once daily, 5 days/week for 2
weeks. Six animals per group were sacrificed after 15 days and remaining
4 animals per group after 30 days.
of severe dermal irritation observed in rabbits treated with TMPTA.
Animals exhibited severe erythema with necrotic skin and eschar
formation, edema, atonia, fissuring of the skin, desquamation and
exfoliation of eschar tissue. Signs of severe irritation persisted in
most animals throughout the post-treatment period. Motor activity
decreased and nasal discharge occurred in several animals in the treated
group, few animals exhibited slight body weight losses.
examination of selected tissues revealed no evidence of systemic
toxicity resulting from administration of TMPTA. Evaluation
of treated skin revealed severe necrosis of the epithelium and upper
dermis (after 15 days) and epithelial and subepithelial dermal necrosis
(after 30 days).
In conclusion, as no systemic substance
related effects were observed the systemic NOAEL of trimethylolpropane
triacrylate (TMPTA) was considered to be > 500 mg/kg bw.
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