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EC number: 239-701-3
CAS number: 15625-89-5
No specific toxicokinetic data available, thus according to ECHA guidance 50% oral absorption in rat is assumed as well as 100% by inhalation
A NOAEL of 300 mg/kg bw/day was identified from an oral rat OECD 422 study. The corrected dermal NOAEL = NOAEL (oral) x ABS (rat-oral)/ABS (derm - human) as given in ECHA guidance R8, example B.5. Assuming an oral absorption of 100% (rat) and using testing data (0.6%) from an in vitro human dermal absorption study (see section 7.1.2) the corrected dermal NOAEL is NOAEL = 300 mg/kg bw/day x 100%/0.6% = 50000 mg/kg bw/day.
The following DNEL values for workers have been considered:
DNEL (inhalation, long-term systemic effects): 3.5 mg/m3
DNEL (inhalation, long-term local effects effects): no adequate data
DNEL (dermal, long-term systemic effect): 83 mg/kg d
DNEL (dermal, long-term local effects): skin sensitiser/ irritant
DNEL (dermal, short term local effects): skin senstiser
Assume same oral absorption rate in rat and human
The following DNEL values for the general population have been
DNEL (inhalation, long-term systemic effects): 0.87 mg/m3
DNEL (dermal, long-term systemic effect): 42 mg/kg /d
DNEL (oral, long-term, systemic effects): 0.5 mg/kg /d
DNEL (oral, short term local effects): No hazard identified
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