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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific principles, acceptable for assessment
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Principles of method if other than guideline:
In an acute inhalation study, rats were exposed to the vapour of the test material at a single concentration for 6 h followed by observation for 14 d.
GLP compliance:
not specified
Test type:
fixed concentration procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Charles River
Sex:
male/female
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 3.26 L/min.
- System of generating vapor: The vapor was generated by bubbling a stream of clean, dry air (-40 °C dewpoint) through the undiluted test material in a gas washing bottle.
- Temperature in air chamber: 24 °C
- Pressure in air chamber: 29.91 inches Hg

Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 6 h
Concentrations:
0.55 mg/L air (nominal)
No. of animals per sex per dose:
5 animals per sex
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 d
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs and body weight
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 0.55 mg/L air (nominal)
Exp. duration:
6 h
Mortality:
No mortality
Clinical signs:
other: No untoward reactions
Body weight:
Body weight gains were within the normal limits
Gross pathology:
No gross pathologic alterations
Other findings:
None

Applicant's summary and conclusion

Conclusions:
Under the test conditions, the inhalation LC50 of the test substance (trimethylolpropane triacrylate - TMPTA) was determined to be greater than 0.55 mg/L after 6 h exposure in rats.
Executive summary:

A study was conducted to evaluate the acute inhalation toxicity of the test substance (trimethylolpropane triacrylate - TMPTA) in rats.

5 Charles River rats/sex were exposed to the vapor of the test substance (trimethylolpropane triacrylate - TMPTA) at a single concentration of 0.55 mg/L air (nominal) for 6 h followed by and observation period of 14 days. Body weight was measured during the observation period and necropsy was performed at the end of this period.

There were no untoward reactions noted during exposure or during the 14 day observation period. The average body weight gains were within the normal limits. Necropsy, performed on all rats at the end of the observation period, did not reveal any gross pathologic alterations.

 

In conclusion, the single median lethal inhalation (LC50) of the test substance (trimethylolpropane triacrylate - TMPTA) was determined to be greater than 0.55 mg/L after 6 h exposure in rats.