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EC number: 239-701-3
CAS number: 15625-89-5
A already sensitized subgroup of workers was used for sensiblisation
patch testing. Seven of the eight affected employees had unequivocal
positive reactions to 1% trimethylol propane triacrylate in petrolatum.
A sensitized subgroup of workers (working in the manufacturing of uv
cured inks) was used for sensitisation patch testing. Seven of the eight
affected employees had unequivocal positive reactions to 1% trimethylol
propane triacrylate in petrolatum. According to the author it is
concluded that triacrylate propane triacrylate appear to be strong
allergens capable of sensitizing a significant percentage of the
workforce exposed to them over a relatively short period of time.
Nevertheless the author hints to the possiblity that some of the
observed reactions represent cross reactions. According to the applicant
the study does not confirm the induction with
triacrylate propane triacrylate and as cross sensitization with/for
other acrylate allergens are reported it is possible that other
substance induced the allergy. Additional the the simultaneous exposure
in this industry to phototoxic materials and to the acrylate monomers
and oligomers may enhance the sensitizing ability of the acrylates.
Nevertheless worker working in the manufacturing of uv cured inks are
potentially exposed to materials leading to a contact dermatitis with
triacrylate propane triacrylate. Because of their allergenicity the the
polyfunctional acrylate monomers and epoxy acrylate oligomers should be
handled carefully with precautions.
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