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EC number: 239-701-3
CAS number: 15625-89-5
A eye irritation study according to the
general techniques as published by the FDA of the(Fed. Reg. 28 (119),
5582, 1963) and Draize and Kelley (Drug Gasmet. Industr. 71 (1952) 36)
was conducted to assess the eye irritation potential of TMPTA.
Therefore two New Zealand White albino
rabbits received 100 milligrams of the test substance. No washout
followed the instillation and the eyes are examined at one hour, 24, 48,
72 hours and 7 days. Ocular reactions are judged using the scoring scale
as published by Draize and Kelley (Drug. Gosmet. Industr. 71 (1952) 36)
During the first day after instillation
the eyes showed slight corneal damage, slight iritis and moderate to
severe lesions of the conjunctivae.
In the course of the seven-day
observation period the degree of corneal
damage increased. After seven days the
following ocular lesions were observed: moderate or moderate-severe
corneal opacity, slight iritis and moderate conjunctivitis.
Results are summarized as follows: eye irritation score (two animais
The author concluded that, according to the classification used, the
test material is moderately irritating to the eye.
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