Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-288-1 | CAS number: 520-26-3
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Hesperidin does not inhibit mobility of daphnia magna as shown in a test with Flavonoides 90% Micro consisting of 90% bw diosmin (a structural analogon to hesperidin) and 10% bw hesperidin. Considering the water solubility of hesperidin being 5 mg/l, the applied concentration was 2-fold above the water solubility of hesperidin (10% of 100 mg/l) and thus the EC50 is considered > 5 mg/l (maximum solubility).
Key value for chemical safety assessment
Additional information
Flavonoides 90% micro, consisting of 90% diosmin and 10% hesperidin did not have any effects on mobility of daphnia magna (48 hours exposure) at 100 mg/l nominal loading rate. Thus, it can be concluded that diosmin as well as hesperidin do not have negative effects on daphnia magna up to 100 mg/l loading rate (see also read across justification in section 13).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
