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EC number: 203-710-0
CAS number: 109-83-1
Low vapor pressure also prevented our
generating high concentrations of 2-MAE. At 150 ppm 2-MAE (mean
concentration from 28 silica gel tubes, one per day, analyzed in
duplicate = 150.0 ppm), no maternal or fetal toxicity was observed (see
Finally, the lack of teratogenic response of
2-methylaminoethanol was interesting and from a mechanistic or
theoretical point of view, would merit follow up using a different route
of exposure. At first glance, one might expect that its
biotransformation would be similar to that of 2-ME. However, our results
of no maternal or fetal toxicity at 150 ppm 2-MAE suggest that this may
not be the case; since the amine is likely more lipidsoluble and less
water-soluble than the methoxy portion, the absorption and excretion of
the 2-MAE is likely quite different from that of 2-ME. Thus it would be
of interest to see if a higher dose of 2-MAE would be teratogenic,
though a route other than inhalation would be required, since the vapor
concentration we used was near the saturation point.' This lack of
teratogenicity at three times the concentration of a teratogenic level
of its structurally similar glycol ether, points to a relatively strict
structural requirement to produce teratogenic effects.
We observed that embryotoxicity decreases as
alkyl chain length increases, similar to observations with testicular
MMEA was vaporized and administered (near the
saturation point) to 18 pregnant rats in one to three concentrations for
7 h/day on gestation days 7 to 15. The dams were sacrificed on day 20 of
gestation. Fetuses were individually weighed, and two-thirds of them
were fixed in Bouin's solution and examined for soft-tissue anomalies.
The other one-third were fixed in alcohol, stained with Alizarin Red and
examined for skeletal defects. As overall result for the substance MMEA,
neither maternal nor fetal toxicity effects were found. No
teratogenicity was observed. The NOAECs were ≥
460 mg/m³, the highest dose tested
for both, dams and fetuses.
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