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EC number: 203-710-0
CAS number: 109-83-1
Low vapor pressure also prevented our generating high concentrations of
2-MAE. At 150 ppm 2-MAE (mean concentration from 28 silica gel tubes,
one per day, analyzed in duplicate = 150.0 ppm), no maternal or fetal
toxicity was observed (Tables 8-10).
Finally, the lack of teratogenic response of 2-methylaminoethanol was
interesting and from a mechanistic or theoretical point of view, would
merit follow up using a different route of exposure. At first glance,
one might expect that its biotransformation would be similar to that of
2-ME. However, our results of no maternal or fetal toxicity at 150 ppm
2-MAE suggest that this may not be the case; since the amine is likely
more lipidsoluble and less water-soluble than the methoxy portion, the
absorption and excretion of the 2-MAE is likely quite different from
that of 2-ME. Thus it would be of interest to see if a higher dose of
2-MAE would be teratogenic, though a route other than inhalation would be
required, since the vapor concentration we used was near the saturation
point.' This lack of teratogenicity at three times the concentration of
a teratogenic level of its structurally similar glycol ether, points to
a relatively strict structural requirement to produce teratogenic
We observed that embryotoxicity decreases as alkyl chain length
increases, similar to observations with testicular atrophy.
The chemical N-Methylethanolamine was vaporized and administered to
approximately 15 pregnant rats in one to three concentrations for 7
hr/day on gestation days 7 to 15, and dams were sacrificed on day 20 of
gestation. Fetuses were individually weighed, and two-thirds of them
were fixed in Bouin's solution and examined for soft-tissue anomalies.
The other one-third were fixed in alcohol, stained with Alizarin Red and
examined for skeletal defects. As overall result for the substance
N-Methylethanolamine it can be stated that neither maternal nor fetal
toxicity effects can be concluded in this study.
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