2-methylaminoethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22. Jun 1965 - 30. Jun 965

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1965

Report date:

1965

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

BASF-Test

Principles of method if other than guideline:

BASF-Test. See further details in remarks on material and methods.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

2-methylaminoethanol

EC Number:

203-710-0

EC Name:

2-methylaminoethanol

Cas Number:

109-83-1

Molecular formula:

C3H9NO

IUPAC Name:

2-(methylamino)ethan-1-ol

Details on test material:

- Name of test material (as cited in study report): Monomethylaethanolamin
- Analytical purity: 99-100 %

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 192 g (mean)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

In the raw data no substance loss but an increase in substance weight was recorded.

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: Inhalation Risk Test

Exp. duration:

8 h

Remarks on result:

other: Inhalation Risk Test

Mortality:

No mortality occured.

Clinical signs:

other: Eye and nose discharge.

Body weight:

The animals gained weight.

Gross pathology:

No abnormalities.

Any other information on results incl. tables

The inhalation of a enriched/saturated vapor-air-mixture caused no mortality within 8 h.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Eye and nose discharge were only the abnormalities noted.

Executive summary:

The acute inhalation test demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (room temperature) (BASF AG, 1965, XV/126). 6 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. The documentation of clinical signs was performed over a period of 7 days.
No mortalities occurred during the observation period. The animals gained weight. Eye and nose discharge were only the abnormalities noted. Gross pathology revealed no signs of toxicity. LC₅₀was not identified.