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EC number: 203-710-0
CAS number: 109-83-1
The data refer to the charged molecule.
Methylaminoethanol is a base. Therefore, Koc
values can be calculated at different pH according to the calculation
approach of Franco and Trapp. The Koc value was the same for the range
of pH 5 - 9 (Koc = 21 L/kg; logKoc = 1.33). This indicates that
surrounding pH will not have a great influence on adsorption
coefficients of methylaminoethanol.
The key value for chemical safety assessment
is estimated using the method of Franco &Trapp (2008).
Adsorption to solid phase
of the N-Methylethanolamine
(CAS 109 -83 -1) is not to be expected.
Article 13 of Regulation (EC) No 1907/2006, it is laid down that
information on intrinsic properties of substances may be generated by
means other than tests, provided that the conditions set out in Annex
XI (of the same Regulation) are met. Furthermore, according to Article
25 of the same Regulation testing on vertebrate animals shall be
undertaken only as a last resort.
to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used
if (1) the scientific validity of the (Q)SAR model has been
established, (2) the substance falls within the applicability domain
of the (Q)SAR model, (3) the results are adequate for the purpose of
classification and labeling and/or risk assessment and (4) adequate
and reliable documentation of the applied method is provided.
the assessment of the N-Methylethanolamine
(CAS 109 -83 -1) (Q)SAR
results were used for the estimation of the adsorption potential. The
criteria listed in Annex XI of Regulation (EC) No 1907/2006 are
considered to be adequately fulfilled and therefore the endpoint(s)
sufficiently covered and suitable for risk assessment.
further experimental studies on the adsorption potential are not
order to assess the adsorption potential of the substance, the Koc
was estimated using QSAR models. According to the MCI method of the
KOCWIN v2.00 module of EPI Suite v4.11, N-Methylethanolamine
109-83-1) has a Koc of
1.30. The MCI module is more reliable than the log Kow method
of KOCWIN v2.00, which estimates the KOC based on the n-octanol/water
partition coefficient (measured logKow:
-0.91; uncharged molecule, BASF AG, BRU 89.018, 1989). The latter
method resulted in a Koc of
0.92. These estimates are representative for uncharged molecules; the
substance is within the applicability domain of the estimation models.
environmentally relevant conditions, N-Methylethanolamine
be present in ionized form (pKa=
9.95 @ 20 °C, HSDB 2010, see IUCLID Ch 4.21). Therefore, the
adsorption coefficient was calculated according to Franco & Trapp
(2008, 2009, 2010) to correct for the charged molecule at pH 5, 7, and
8. This pH range is representative for 98 % of the European soils. The
model is not yet validated; in addition, the applicability domain is
not clearly defined. Nevertheless, the Koc values
of the Franco & Trapp method give a good indication on the adsorption
potential of a substance depending on the pH conditions of soil. The
method is based on the dissociation constant pKa and
the log Kow for
the uncharged molecule.
resulting Koc at
pH 5-8 is 21 L/kg (log Koc:
can be concluded that adsorption to the solid soil phase is not
expected under environmentally relevant conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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