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EC number: 203-710-0
CAS number: 109-83-1
Dose (mg/kg bw)
No mortality occured during the 14 -day
observation period in both sexes.
There is indication that the test substance
causes local irritation to the exposed tissue.
acute dermal toxicity of 2-methylaminoethanol was determined for White
Vienna rabbits (BASF AG, 1981). For this purpose, the product was
applied once for 24 hours to the clipped skin of the back and flank
(area about 50 cm²) unchanged in a dose of 2000 mg/kg. The treated area
of skin was then covered with an inert foil, which was secured in
position with adhesive tape. The bandage was removed after an exposure
period of 24 hours; subsequently, the test substance was washed off with
warm water and dried with cellulose. The LD50was determined
taking into account the DOT guidelines, but it was not established
No mortalities occurred during the study. Following signs of systemic
toxicity were observed by treated animals: dyspnoea, apathy, staggering,
salivation, cry of pain and poor general state. After 24 hours, soft
anemic necrosis, severe edema, pea-size 3 mm deep ulcers appeared. After
7 days these ailments progressed to parchment-like necrosis, slight
edema and wrinkles. After 14 days, leathery-like necrosis wrinkles
partially open and weeping was still present in the treated animals.
Gross pathology revealed no abnormalities.
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