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EC number: 201-622-7
CAS number: 85-68-7
Butyl benzyl phthalate was assessed for repeated-dose toxicity in B6C3F1 mice.
Groups of 50 mice of each sex were given the test substance in the diet for 103 weeks at concentrations of 0, 6000 or 12000 ppm (providing around 0, 780 or 1560 mg/kg bw/day). The mice were observed daily for clinical signs of toxicity, body weight changes were recorded every 4 weeks, and the animals were sacrificed at 106 weeks. A comprehensive range of organs and tissues was examined for gross and microscopic changes.
A dose-related decrease in mean body weights of both male and female mice was observed throughout the study. Statistical significance was not reported, but the reduction in body-weight gain appeared to be around 5% and 5-10% in low-dose males and females respectively, and 15% and 10-25% in high-dose males and females respectively. No other compound-related clinical signs were observed and survival was comparable in the control and treated groups. No toxic lesions were evident and all histological changes observed were similar in both treated and control groups and within the normal historical incidence limits in B6C3F1 mice. Similarly the neoplastic effects observed were deemed to be unrelated to administration of the test substance and also fell within the range of historical controls.
When male and female B6C3F1 mice were given butyl benzyl phthalate in the diet at 0, 6000 or 12000 ppm for 103 weeks (equivalent to a nominal dose of around 0, 780 or 1560 mg/kg bw/day), growth inhibition occurred in the BBP-treated groups (particularly at the top dose) but there was no other evidence of compound-related toxicity. The NOAEL was 6000 ppm (780 mg/kg bw/day).
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