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EC number: 201-622-7
CAS number: 85-68-7
Uniform distribution of vapour and aerosol within exposure chambers
throughout the study; >90% of particles were <10 µm;
some vapour existed at the high and mid exposure levels.
Urine-stained fur and chromodacryorrhea were observed in both sexes in
the mid- and high-exposure groups. Although the investigators described
these findings as "seemingly compound and dose-related", the EU RAR made
no mention of chromodacryorrhea but stated that urine-stained fur,
piloerection and alopecia "were not considered as reliable indicators of
the test compound". Increased relative liver and kidney weights were
seen at the top dose, and males in this group had a marked decrease in
serum glucose at terminal sacrifice, leading the EU RAR to set a
no-observed-adverse-effect concentration (NOAEC) of 0.218 mg/l.
In a reliable study, an NOAEC of 0.218 mg/l was established for rats
exposed to benzyl butyl phthalate by inhalation for 6 hours/day on 5
days/week for 13 weeks. Increased relative liver and kidney weights were
observed at the higher test concentration of 0.789 mg/l, although there
were no accompanying histopathological findings. The study was performed
in compliance with GLP.
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