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EC number: 201-622-7
CAS number: 85-68-7
Butyl benzyl phthalate was assessed for its
ability to induce chromosome aberrations in Chinese hamster ovary cells.
Cells were incubated with concentrations of
the test substance of up to 1250 ug/mL for 2 hr with S9, or 14 hr
without S9. Cells that had been exposed with S9 were placed in fresh
medium and incubated for a further 12 hr.; colcemid was added as a
spindle inhibitor to all cultures 2 hr before harvesting the cells.After
fixation and staining, 100 first-division metaphases per dose were
scored for all types of chromosome aberrations.
test substance did not increase the frequency of aberrations, compared
to the vehicle controls.
benzyl phthalate did not induce chromosome aberrations in an in vitro
assay with Chinese hamster ovary cells, either in the presence or
absence of a rat liver metabolic activation fraction.
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