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EC number: 201-622-7
CAS number: 85-68-7
Excretion yields for benzylbutylphthalate, on a molar basis, for the
low- and high- dose groups respectively:
- Day 1 (24 hours after dosing):
- MBeP: 67% and 78%
- MBuP: undetectable, 6%
Groups of 8 human volunteers were administered 0, 253 or 506 µg
benzylbutylphthalate in a radioactively-labelled, deuterated form (d4-BBP).
The phthalate dose was spiked into margarine and spread on toast as
breakfast. During the day prior to dosing, the day of dosing and days
2 and 6 post-dosing, 24-hour urine samples were collected and analysed
for d4-phthalate monoester metabolites.
In the first 24-hours post dosing, the mean amounts of d4-monobenzylphthalate
detected in the urine were 140 and 323 µg (with relative standard
deviations of 39% and 26%) in the low- and high-dose groups,
respectively, representing excretion yields (conversion rates) of 67
and 78%, respectively, on a molar basis. At the high dose, 20 µg d4-monobutylphthalate
(relative standard deviation 59%) was also excreted, representing a
conversion rate of 6%, but at the low dose it was undetectable. Both
metabolites were undetectable in urine collected during days 2 and 6
In a reliable human study, monobenzylphthalate was identified as the
main metabolite and monobutylphthalate as a secondary metabolite after
a single oral administration of benzylbutylphthalate to groups of 8
volunteers at around 3.6 or 7.2
µg/kg bw. Both monoesters were eliminated rapidly during the first
24 hours after dosing.
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