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EC number: 201-622-7
CAS number: 85-68-7
Butyl benzyl phthalate gave a weak
positive result at a dose of 5000 mg/kg bw when sampled at 17 hr post
treatment only. Trend analysis was also positive in studies 2 and 3
Study 1 (36 hr sampling)
Study 2 (17 hr sampling)
Study 3 (17 hr sampling)
% cells with
% cells with
Butyl benzyl phthalate was assessed for
its ability to induce chromosome aberrations in the bone marrow cells of
In two separate studies, groups of eight
male mice were injected intraperitoneally with either 0, 1250, 2500 or
5000 mg/kg bw of the test compound, another group received
dimethylbenzanthracene (positive control) and cells were harvested at
either 17 or 36 hr after treatment. In a further study mice were dosed
with 0, 2500, 3750 or 5000 mg/kg bw and cells were harvested at 17 hr.
The mice were subcutaneously implanted with a bromodeoxyuridine tablet
18 hr before harvesting, and injected with colchicine 2 hr before
harvesting of the cells. Bone marrow cells were collected from the
femurs of each animal, washed, fixed and spread on slides before
staining. Fifty first-division metaphases from each animal were scored
for all types of chromosome aberrations. The mean number of aberrations
and the mean percentage of cells containing aberrations (excluding gaps)
were determined for each treatment group. The mitotic index was not
determined as an indicator of cytotoxicity.
In both studies in which cells were
harvested at 17 hr post treatment, a weak (but statistically
significant) increase in aberrations was seen only at 5000 mg/kg bw.
There was no such increase at the delayed 36-hr sampling time.
In an in vivo assay for chromosome
aberrations in which mice were treated by a single intraperitoneal
injection, butyl benzyl phthalate showed a weak positive response in the
bone marrow at the top dose of 5000 mg/kg bw.
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