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EC number: 201-622-7
CAS number: 85-68-7
In a reliable dermal absorption study, 14C-labelled
benzylbutylphthalate was applied to the shaved skin of three male rats
at a dose of 49 mg/kg bw on an area of 1.3 cm2. The
application was semi-occluded for 7 days during which time urine and
faeces were collected. At study termination, samples of a number of
tissues were taken. Radioactivity was determined in all these tissues
The proportion of the administered dose found in the tissues and excreta
after 7 days was
30% in urine and faeces, 4.6% in muscle, <0.5% in brain, spinal cord and
testis, 0.17% in adipose tissue and
Covered application of 14C-benzylbutylphthalate on the shaved skin of
rats (to an area of 1.3 cm2) at 49 mg/kg bw (7.7 mg/cm2) for 7 days
resulted in approximately 35% dermal absorption over this period,
equivalent to 5% per day.
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