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EC number: 201-622-7
CAS number: 85-68-7
Acute toxicity tests with butyl benzyl phthalate in rats and mice (oral, up to 20 g/kg bw), rabbits (dermal, up to 10 g/kg bw), and rats (inhalation, saturated vapour) indicate that this compound does not need to be classified for acute toxicity.
In a reliable study,
butyl benzyl phthalate was assessed for acute oral toxicity in male and
female F344/N rats and B6C3F1 mice (NTP, 1982). Groups of five rats and
five mice of each sex were dosed with up to 20 g/kg bw by oral gavage,
and surviving animals were observed for 14 days. Deaths occurred in rats
at 2.5 g/kg bw and above and in mice at 5 g/kg bw and above. The LD50
value was estimated to be 2.33 g/kg bw for rats (of both sexes), 6.16
g/kg bw for male mice and 4.17 g/kg bw for female mice. These figures
indicate that butyl benzyl phthalate is of low acute oral toxicity to
rats and mice. This is supported by another rat study for which few
details are available (hence
it has been assigned reliability code 4), with an
acute oral LD50 value of 20.4 g/kg bw (Birch,
When neat Santicizer
160 (butyl benzyl phthalate) was applied to the skin of four New
rabbits at doses of around 4, 6 and 10 g/kg bw for
an exposure period of 24 hours, there were no deaths in the subsequent 2
-week observation period, although the animals showed reductions in
appetite and activity.
[It is not clear which doses had these effects.] The viscera appeared
normal on gross necropsy. The
investigators concluded that the LD50 was greater than 10 g/kg bw
(Birch, 1976b). Although details are only available in a brief summary
report (hence it has been assigned reliability code 4), the data are
considered adequate for assessment.
When four male rats
were exposed for 6 hours to a saturated atmosphere containing Santicizer
160 (benzyl butyl phthalate) and observed for 3 days, there were no
deaths and only mild transient effects, including irregular breathing,
moderate lethargy and mild nasal irritation. There is no information
provided on the actual test concentration (Younger,
Acute oral, dermal and inhalation toxicity studies on butyl benzyl
phthalate are considered adequate for concluding that the compound does
not need to be classified for acute toxicity, under the EU CLP
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