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EC number: 201-622-7
CAS number: 85-68-7
Santicizer 160 (0.1 ml) was placed in the eyes of six New Zealand albino
rabbits, and removed after 24 hours (presumably by rinsing). The treated
eyes were assessed for signs of irritation during the 7-day observation
period, and the data scored according to the method of FHSA.
after the 24-hour exposure period, slight discomfort was observed and
after 10 minutes copious discharge was noted. At 1 hour after removal of
the test material, copious discharge and slight erythema were reported,
giving a mean irritation score of 8 out of a possible 110. At 24-hours
post-exposure, slight erythema and slight to moderate discharge were
reported (mean irritation score of 4.3/110). All effects were on the
conjunctivae. Eyes appeared normal when examined 48, 72, 120 and 168
hours after removal of the test material, giving an overall irritation
score of 1.43 (average of scores assessed at 24, 48 and 72 hours post
exposure). The investigators classed the test material as slightly
irritating to the eyes of rabbits, but noted that it would not be
classed as an eye irritant under FHSA. Similarly under EU CLP
regulations, this study would indicate that Santicizer 160 is not an eye
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