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EC number: 925-259-5
CAS number: 140921-24-0
The test substance was tested in a mouse micronucleus assay according OECD guideline no. 474 and EU method B.12. Possible clastogenic effect to the chromosomes of bone-marrow erythroblasts of the test substance were investigated in male and female mice.
The treated animals received a single intraperitoneal administration of either test substance or cyclophosphamide (positive control). The femoral marrow of groups treated with test substance was prepared 16, 24 and 48 hours after administration. All negative and positive control animals were sacrificed after 24 hours. The doses of test substance and positive control were 15 and 20 mg/kg bw, respectively. The animals treated with test substance showed symptoms of toxicity after administration. One of the forty animals died before the end of the test due to the acute inraperitoneal toxicity of 15 mg/kg test substance. There was weekly altered ratio between polychromatic and normochromatic erythrocytes.
The results with the test substance gave no relevant indications of clastogenic effects after single intraperitoneal treatment with 15 mg/kg. The known mutagen and clastogen, cyclophosphamide, had a clear clastogenic effect at an intraperitoneal dose of 20 mg/kg bw. The number of micronucleated polychromatic erythrocytes increased to a biologically relevant degree.
The number of microncleated normochromatic erythrocytes did not increase relevantly in any of the groups. The test substance was judged to be not clastogenic in vivo.
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