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EC number: 411-700-4
CAS number: 140921-24-0
HÄRTER VERSUCHSPRODUKT LS 2959E; HÄRTER VP LS 2959E
The test substance was investigated in the Salmonella / microsome test for point-mutagenic effects in doses up to 5000 µg per plate on four Salmonella typhimurium LT2 mutants. These comprised the histidine-auxotrophic strains TA 1535, TA 100, TA 1537 and TA 98. Doses up to and including 200 µg per plate did not cause any bateriotoxic effects: Total bacteria counts remained unchanged and no inhibition of growth was observed.
At higher doses, the substance had a strain-specific bacteriotoxic effect, so that this range could only be used to a limited extend up to 5000 mg per plate for assessment purposes. Evidence of mutagenic activity for the test substance was not seen. No biologically-relevant increase of the mutant count, in comparison with the negative controls, was observed. Therefore, the test substance was considered to be non-mutagenic without and with S9 mix in the Salmonella/microsome test. The positive controls sodium azide, nitrofurantoin, 4-nitro-1,2 -phenylene-diamine and 2 -aminoanthracene had a marked mutagenic effect, as was seen by a biologically-relevant increase in mutant colonies compared to the corresponding negative controls.
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