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EC number: 411-700-4 | CAS number: 140921-24-0 HÄRTER VERSUCHSPRODUKT LS 2959E; HÄRTER VP LS 2959E
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1992-07-14 to 1992-08-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- GLP study, but no internationally accepted guideline followed
- Principles of method if other than guideline:
- internal method: 2011-0340301-92D, SFC method
- GLP compliance:
- yes
- Key result
- Medium:
- other: fat simulative medium HB 307 (NATEC)
- Remarks on result:
- other: 138.5 g per 1000 g fat
- Test substance stable:
- not determined
- Details on results:
- The fat solubility was determined using SFC method and an internal standard (peak area analysis).
- Conclusions:
- The fat solubility of the test item was determined to be 138.5 g per 1000 g fat.
- Executive summary:
The fat solubility of the test item was determined to be 138.5 g per 1000 g fat.
Reference
Starting from under-saturation:
- 135.1 g per 1000 g fat (1 h at 30 °C)
- 144.2 g per 1000 g fat (3 h at 37 °C)
- 142.9 g per 1000 g fat (1 h at 30 °C)
- 135.1 g per 1000 g fat (24 h at 37 °C)
Starting from over-saturation:
- 141.6 g per 1000 g fat (1 h at 50 °C)
- 140.3 g per 1000 g fat (3 h at 37 °C)
- 135.1 g per 1000 g fat (1 h at 50 °C)
- 133.8 g per 1000 g fat (24 h at 37 °C)
Mean value: 138.5 g/ 1000 g fat (standard deviation: 4.2)
- Other: The system fat/test item is a system showing partial miscibility. At the mixing ration fat : test item = 1:1 and 1:10 (wt%) a complete miscibility was observed (in pre-tests). At the mixing ration fat : test item = 10:2 (wt%) two phases coexist. In this system the test item is in the fat phase having a concentration of 178 g/1000 g fat and a solubility of 138.5 g/1000g fat. This system (fat in excess) is therefore a system with a miscibility gap.
Description of key information
The fat solubility of the test item was determined to be 138.5 g per 1000 g fat.
Key value for chemical safety assessment
- Solubility in mg/100g standard fat:
- 13 850
- At the temperature of:
- 20 °C
Additional information
The fat solubility of the test item was determined to be 138.5 g per 1000 g fat.
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