Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-847-9
CAS number: 127-52-6
Sodium N-chlorobenzenesulphonamide – Chloramine B
(trihydrate) was administered to female rabbits at dose levels of 10, 30
and 90 mg/kg bw/day orally, by gavage from the 6th to 28th day of
pregnancy. In addition, a restricted feeding control was employed
consisting of untreated dams which were offered the food amount consumed
by the high dose dams. Under the present test conditions, the
no-observed-effect level (NOEL) was 10 mg/kg bw/day for the dams.
Transient slight or moderate reductions were noted for the body weight
and food intake of the dams treated with 30 mg /kg bw/day. Distinct
reductions of body weight and food consumption, especially during the
first days of treatment, were noted at 90 mg/kg bw/day. Similar
reductions of body weight and food intake were noted in the untreated
dams with restricted feeding.
The no-observed-effect level (NOEL) for the fetal
organism also was 10 mg Sodium N-chlorobenzenesulphonamide-Chloramine B (trihydrate)/
kg bw /day. A dose level of 30 mg/ kg bw /day resulted in
increased incidences of total skeletal retardations, in particular
sternebra(e) not ossified. The severely materno-toxic dose level of 90
mg/kg bw /day resulted in developmental retardations in the form of
reduced placental and fetal body weights compared to the control.
Skeletal examination (according to DAWSON) revealed increased fetal
incidences for variations of the sternum (fusions) and total skeletal
variations as well as retardations of the sternum and lumbar vertebral
bodies (incomplete or missing ossification) and total skeletal
No test item related malformations were noted
during external, internal or skeletal examination (according to DAWSON)
of the fetuses or soft tissue examination of the fetal heads (according
to WILSON) at any tested dose level, not even at materno-toxic dose
No embryotoxic changes were noted for the
restricted feeding group. In conclusion, the test item possessed no
Chloramine B trihydrate revealed slight embryotoxicity at materno-toxic
dose levels (30 or 90 mg Sodium N-chlorobenzenesulphonamide – Chloramine
B/ kg bw/day).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again