Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-847-9
CAS number: 127-52-6
1 Excretion of HO36Cl in ratsa
Collection period (h)
Proportion of HO36Cl excreted (%)
represent mean±SE from four treated (fasted) rats, expressed as the
proportion of administration dose. 36Cl was not detected in expired air
throughout the 96 h studied.
2 The distribution of 36Cl activity 96 h
after administration of HO36Cl orally
36Cl activity (µg/g)
of Chloramine-T after single 30 mg/kg i.v. and 100 mg/kg p.o. were
studied in male Wistar Rats. Serial blood samples were collected and
plasma concentrations of Chloramine-T were determined by HPLC
method. Chloramine-T was characterized by a rapid distribution and
elimination phase (distribution half-life 0.12 hr – i.v. and 0.42 hr. –
p.o.; elimination half-life 1.41 hr – i.v. and 1.98 hr – p.o.). Plasma
clearance was relatively high (0.147 L/hr – i.v., 0.149 L/hr – p.o.)
with a volume of distribution at steady state of 0.24 L. Chloramine-T
was found to be rapidly distributed and eliminated. After 96 h, 36% was
eliminated via the urine, whereas 15% was eliminated via faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again