Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-847-9
CAS number: 127-52-6
The test substance Chloramin B trihydrate was
tested in in vivo micronucleus test for the detection of chromosome
The test was performed according to OECD Test
Guideline No. 474 – Genetic Toxicology: Micronucleus Test. The
test substance was administered to the mice of ICR strain
intraperitoneally in multiple dose regime: 3 doses with 24-hour interval
between dosing. The doses administered were as follows: 3 x 20 and 3 x
30 mg/kg in males, resp. 3 x 40 and 3 x 65 mg/kg in females.
Cytogenetic effect was evaluated at two cell
harvesting times: 24, 48 hours after last administration. Under the
experimental design described above, the result of mouse micronucleus
test with test substance Chloramin B, was negative. The test substance
did not induce the micronuclei in the immature erythrocytes in bone
marrow of mice therefore it is considered non-mutagenic in this test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Damit Sie die Website optimal nutzen können, verwenden wir Cookies.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again