Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-847-9
CAS number: 127-52-6
The results of the key study show that the test substance is highly toxic to algae. The most sensitive NOEC is < 0.017 mg/L based on biomass. The corresponding EC50 is 0.029 mg/L. NOEC and EC50 values based on growth rate are 0.053 and 0.141 mg/L. Values are calculated based on average measured exposure concentrations.
Analytical work of the
key study showed the test substance disappeared from the test solutions
during 3 days of incubation. The disappearance rate was dose-dependent.
Disappearance was complete on day 3, at average exposure concentrations0.1
to 0.67 mg/L (nominal), whereas10.1
and 15.1 % of the test substance were still present at 1.07 mg/L and 1.7
mg/L (nominal). Presence or absence of algae did not significantly
influence the rate of disappearance.
A supporting study
which was conducted with the purpose to explain the analytical findings
of the key study showed that the test substance was de-chlorinated with
concentration of the test substance decreases, the concentration of
de-chlorinated test substance, i.e. Benzenesulfonamide (CAS
De-chlorination was dose dependent. Within one dose group, comparable
de-chlorination rates were found in deionised water, algae medium and
algae medium stocked with algae.
This indicates, that
rather the testing conditions, than the presence of algal medium and
algae cells, e.g. permanent agitation of the solution in semi-open
vessels at rather high temperatures and light intensities, caused the
de-chlorination of CAS 127-52-6. Based on the results of a valid
hydrolysis study, the substance is stable at pH 7 and 9 in deionised
water, i.e., no de-chlorination takes place. Abiotic degradation is
analyzed in closed vessels in the dark, without agitation and air
exchange. Hence, the results obtained are considered artifacts of the
specific test design used for algae growth inhibition test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again