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EC number: 204-847-9
CAS number: 127-52-6
The test Substance Chloramin B trihydrate was assayed for
the mutagenicity by the Bacterial Reverse Mutation Test. The test was
performed according to OECD Test Guideline 471 Bacterial Reverse
Mutation Test which is analogous to the EU method B.13/14. Four
indicator Salmonella typhimurium strains TA 98, TA 100, TA 1535 and TA
1537 and one indicator Escherichia coli WP2uvrA strain were used. The
test substance was dissolved in demineralized water and assayed in doses
of 0.3-100 µg which were applied to the plates in emulsion in amount of
0.05 mL. Two series of experiments were performed with
each strain- without metabolic activation and with supernatant of rat
liver and a mixture of cofactors. In the arrangement
given above, the test substance Chloramin B trihydrate was nonmutagenic
for all used bacterial strains with as well as without metabolic
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