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EC number: 204-847-9
CAS number: 127-52-6
No detailed data for neurotoxic effects of sodium
N-chlorobenzenesulphonamide are available.
Neurotoxicity assessment is based on the similarity of
chloramine B trihydrate (active substance sodium
N-chlorobenzenesulphonamide trihydrate) and chloramine T (active
substance tosylchloramide sodium). Upon read-across it may be assumed
that chloramine B will have similar neurotoxic effects as chloramine T.
Tosylchloramide sodium was used to mimic the effects of free radicals
and active oxygen compounds implicated in brain ischemia and head
trauma. Previous studies showed that free radicals produced both
synaptic and postsynaptic damage in guinea pig hippocampal brain slices.
Tosylchloramide sodium (25 to 500µM [7.0 to 140.8µg/mL]) decreased both
the population spike and population postsynaptic potential. However, the
ability of the population postsynaptic potential was not impaired by the
treatment. These studies suggest that oxidation reactions account for
the synaptic component of free radical-induced damage in the nervous
system but not the postsynaptic effects. (1)
In a 90-day subchronic toxicity test all animals were
observed also for neurotoxic effects. Functional observations were
conducted at the end of exposure period as well as the recovery one. The
sensory reactivity to auditory, visual, proprioceptive stimuli and
papillary reflex was evaluated and assessment of grip strength and motor
activity was conducted. No negative effects were found and Chloramine-B
trihydrate was tolerated without adverse effects in male and female rats
at the administered doses up to 20 mg/kg/day.
Summaries and evaluations in this section are based
mostly on exhaustive and reliably peer reviewed documents: Chloramine T
(CAS 127-65-1) and Metabolite p-Toluenesulphonamide (CAS 70-55-3),
Review of Toxicological Literature, 2002, 16.
(1) Pellmar T.C., and K.L. Neel. 1989. Oxidative damage
in the guinea pig hippocampal slice. Free Radical Biol Med 6:467-472.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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