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EC number: 204-847-9
CAS number: 127-52-6
Table 1 Body weight of animals [in grams]; Dose:
Before application M/F*
Table 2 Clinical observation; Dose: 2000 mg.kg-1;
Sex: M and F
Tendency for death/death
Toxic effect description
No clinical signs of toxicity; skin crusts
Pathological examination; Dose: 2000 mg.kg-1; Sex: M and F
Toxic effect findings for M and F
Skin crusts; spleen – granular surface
Chloramine B trihydrate was tested for dermal
toxicity in a limit test with two groups of animals (5 males and 5
females) at the dose of 2000 mg/kg bw. The test substance was applied
occclusively on the shaved skin of the test animals moistened witht a
small amount of water for 24 hours. The test animals were observed 14
days after application, afterwards sacrificed and necropsy for
macroscopic examination of the organs was performed. The test substance
applied at the dose 2000 mg/kg bw did not cause death of animals. No
clinical signs of toxicity were observed during the study in all
animals, except for symptoms of skin irritation which were almost
healed. Macroscopic changes were diagnosed during pathological
examination in all animals (skin: crusts; spleen: granular surface).
According to the study results the value of LD50 dermal
of the test substance Chloramin B for rats of both sexes is higher than
2000 mg/kg bw.
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