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EC number: 204-847-9
CAS number: 127-52-6
TABLE 1. TABLE
FOR ACUTE TOXICITY
Animal weight (g)
Weight increment (g)
Step No. 1 (Dose – 2000 mg/kg)
30 minutes: erected hair, anaemic cutis and anaemic mucous membrane, abdominal position, immobility, gasping, no reaction to stimulation
2.5 hours: death
Stomach – dilatation, hyperaemia, acute catarrhal inflammation
Small intestine - acute catarrhal inflammation
Step No. 2 (Dose – 300 mg/kg)
30 minutes: no clinical signs of intoxication
3 hours: no clinical signs of intoxication
2nd– 14th day: no clinical signs of intoxication
Liver - dystrophia
Liver – dystrophia
Step No. 3 (Dose – 300 mg/kg)
2nd– 14thday: no clinical signs of intoxication
Chloramin B was administered via oral gavage in a
single dose as a solution in water for injection. The
dosing was performed sequentially in three groups of three females:
group No. 1 (first step) using the starting dose of 2000 mg/kg bw, group
No. 2 (second step) and group No. 3 (third step) using a dose of 300
mg/kg bw. The dose volume of administered solution did not exceed
2mL/100g bw of animals.
The test substance administered at the dose of 2000 mg/kg bw caused
death of all three animals, clinical signs of intoxication were observed
in all three animals and macroscopic changes were diagnosed during
pathological examination in all three animals. The
test substance administered at the dose of 300 mg/kg bw caused no death
in females, very mild clinical signs of intoxication were observed in
three animals (erected hair, hunched posture) and macroscopic changes
were diagnosed during pathological examination in three females.
According to the study results the value of LD50of
the test substance Chloramin B for rats is in the range > 300 mg/kg bw
to ≤ 2000 mg/kg bw. The exact value was not given in the report, but can
be considered to be around 1150 mg/kg bw.
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